环生医-秦国华教授、博导_教授_山西大学环境与资源学院

教授

环生医-秦国华教授、博导

2013-12-01

秦国华教授，博导，女，山西省优秀青年学术带头人，主要从事环境科学及环境生物医学方面的教学科研工作。

主讲山西省精品共享课程《环境管理与法学》，是国家级一流课程及山西省课程思政示范课《环境生物学》第二负责人；主持或参与山西省教学改革项目2项；获山西省教学成果特等奖一项。

主持国家自然科学基金项目4项，中国博士后科学基金特别资助项目1项，面上项目1项，省部级及其他项目9项；发表学术论文70余篇，其中 SCI收录论文36篇；参编著作3本；获山西省科技进步二等奖1项。

代表性工作包括：（1）大气污染物对糖脂代谢的健康影响；（2）大气污染物对心血管系统的健康影响；（3）昆虫抗性机制的研究。

Prof. Qin is mainly engaged in the research on environment, health and ecotoxicology. Her representative works include: (1) health effects of air pollutants on carbohydrate, lipid metabolism, and cardiovascular health; (2) insect toxicology study of the air pollutants. She has presided over 3 projects of the National Natural Science Foundation of China, 2 projects of the China Postdoctoral Science Foundation, and over 4 provincial and ministerial scientific research projects. She has published more than 60 research papers. She has won the second prize of scientific and technological progress of Shanxi Province.

电子邮件：qinguojua@sxu.edu.cn

社会服务和兼职

1. 《Sustainability》guest editor

2. 中国高等教育学会生态文明教育研究分会会员

3. 山西省人大常委会城环工委咨询专家

近五年主持科研项目：

1. 基于果蝇模型研究多世代长期臭氧暴露导致代谢紊乱及发育异常的机制（22276118）国家自然科学基金 2023.01-2026.12, 资助额:54万元2023.1-2026.12

2. 大气细颗粒物致肝脏脂质代谢紊乱的机制研究 (2021) 北京市科学技术研究院城安全与环境所职业安全健康 重点实验室开放基金 2021.11-2022.11, 资助额:5万元

3. 大气细颗粒物诱导肝脏脂肪变性的关键组分识别及作用机制研究（22076109）国家自然科学基金 2021.01-2024.12, 资助额:63万元

4. PM2.5诱导心脏功能紊乱:基于关键毒性组分在心肌肥大/纤维化发生发展中的作用研究 (21777091 ) 国家自然科学基金 2018.01-2021.12, 资助额:64万元

5. PM_2.5中关键有机组分诱导心肌纤维化的作用 (KF2016-17) 环境化学与生态毒理学国家重点实验室开放基金 2017.01-2018.12, 资助额:5万元

6. 不同季节PM_2.5暴露对心肌肥大及纤维化的作用 (GZKLEEH201612) 广州市环境暴露与健康重点实验室开放基金2016.05-2018.04, 资助额:4万元,

近五年代表性论文

1. Nan Nan, Zhipeng Yan, Yaru Zhang, Rui Chen*, Guohua Qin*, Nan Sang. Overview of PM 2.5 and health outcomes: Focusing on components, sources, and pollutant mixture co-exposure. Chemosphere. 2023,138181

2. Zhipeng Yan ^#, Shuyue Li ^#, Rui Chen ^#, Haohan Xie, Meiqiong Wu, Nan Nan, Qisong Xing, Yang Yun, Guohua Qin *, Nan Sang. Effects of differential regional PM_2.5 induced hepatic steatosis and underlying mechanism. Environ Pollut. 2023, 323: 121220.

3. Xing Qisong^#, Wu Meiqiong^#, Xue Zhen, Nan Nan, Yan Zhipeng, Li Shuyue, Yun Yang*, Qin Guohua*, Sang Nan. Biochemical evidence of PM_2.5 critical components for inducing myocardial fibrosis in vivo and in vitro. Sci Total Environ. 2023, 857: 159258.

4. Wu Meiqiong, Xing Qisong, Duan Huiling, Guohua Qin*, Sang Nan. Suppression of NADPH oxidase 4 inhibits PM _2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway. Sci Total Environ. 2022; 837:155558. Sep 1

5. Nan Nan^#, Huiling Duan ^#, Xiaofeng Yang^#, Lei Wang, Aiqin Liu, Rui Chen, Guohua Qin*, Nan Sang. Atmospheric PM_2.5-bound polycyclic aromatic hydrocarbons in China’s four cities: Characterization, risk assessment, and epithelial-to-mesenchymal transition induced by PM2.5. Atmospheric Pollution Research. 2021; 12:101122

6. Xiaoqin Feng, Jinhong Luo, Xiaocheng Wang, Wolong Xie, Jiao Jiao, Xiaohui Wu, Lingling Fan, Guohua Qin*. Association of exposure to ambient air pollution with ovarian reserve among women in Shanxi province of north China. Environ Pollut. 2021; 278:116868.

7. Qisong Xing^#, Meiqiong Wu^#, Rui Chen ^#, Gang Liang, Huiling Duan, Shuyue Li, Yuqian Wang, Lei Wang, Caixiu An, Guohua Qin*, Nan Sang. Comparative studies on regional variations in PM_2.5 in the induction of myocardial hypertrophy in mice. Sci Total Environ. 2021; 775:145179. Jun 25

8. Li Shuyue^#, Xu Zhifang^#, Xia Jin, Qin Guohua*, Sang Nan*. Sulfur dioxide induces apoptosis via reactive oxygen species generation in rat cardiomyocytes. Environ Sci Pollut Res Int. 2019;26(9):8758-8767.

9. Wu Meiqiong, Liang Gang, Duan Huiling, Yang Xiaofeng, Qin Guohua*, Sang Nan*. Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p/ transforming growth factor β type II receptor axis. Chemosphere. 2019, 219: 268-276. 2019.3

10. Wang Ruixia, Chen Rui*, WangYoufeng, Chen Lan, Qiao Jiyan, Bai Ru, Ge Guanglu, Qin Guohua*, Chen Chunying*. Complex to simple: In vitro exposure of particulate matter simulated at the air-liquid interface discloses the health impacts of major air pollutants. Chemosphere. 2019 Feb 7;223:263-274. doi: 10.1016/j.chemosphere.2019.02.022.

11. Qin Guohua, Xia Jin, Zhang Yingying, Guo Lianghong, Chen Rui and Sang Nan*. Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice. Particle and Fibre Toxicology. 2018, 15:27.

12. 冯晓琴, 罗锦洪, 谢卧龙, 王娜, 秦国华*，大气污染暴露与育龄妇女月经周期长度的关联. 中国环境科学，2023, 43 (1): 374-382

13. 南楠, 闫志鹏, 张亚如, 秦国华*, 桑楠. 果蝇胰岛素样肽8(Dilp8)的功能及作用机制. 昆虫学报，2022, 65(12): 1695-1700. 2022.12.20

14. 闫志鹏,李舒月,邢颀颂,南楠,秦国华*,桑楠. 不同城市PM2.5致小鼠肝脏纤维化的效应差异研究. 中国环境科学, 2022,42(6):2878-2885

15. 邢颀颂，梁刚，武美琼，秦国华*，桑楠. 不同城市PM2.5对易感小鼠线粒体损伤的影响. 中国环境科学，2019, 39(12):5319-5325

16. 段慧玲，夏瑾，梁刚，秦国华*，桑楠. PM2.5对小鼠和H9C2 细胞心肌肥大相关因子mRNA表达的影响. 环境科学学报，2019,39(3):978-984

17. 夏瑾，秦国华*，桑楠. 抗氧化剂对二氧化硫诱导的大鼠心脏线粒体损伤的缓解作用. 中国环境科学，2018,38(8)：3129~3134

18. 梁刚，夏瑾，秦国华*，桑楠. PM2.5暴露导致老年小鼠可逆性心肌肥大. 环境科学学报，2018，38(8)：3361-3366

出版著作：

1. 空气颗粒物与健康，ISBN: 978-7-5706-0341-1湖北科学技术出版社，2019-10，p90-101

2. 二氧化硫生物学：毒理学·生理学·病理生理学，ISBN：978-7-03-034073-3 科学出版社，2012-5，p63-67, p 154-179

3. 生活方式与健康, ISBN：978-7-110-07070-3 科学技术普及出版社,2009-6,p66-107

科研获奖

1. 张建珍，刘晓健，张建琴，张学尧，秦国华，马恩波. 重要农业害虫分子毒理学与几丁质代谢研究山西省科学技术二等奖 2016-Z-2-004