副教授

姓名：樊丽

职称：副教授

所在专业：环境科学与工程

个人简介：主要从事新型荧光探针的合成与应用、化学与生物传感分析，环境分析化学等方面的研究工作。

招生方向：分析化学、环境分析等专业研究生

联系方式：Email: fanli128sxu.edu.cn；Tel: 13834643453

教育背景：

1999.9-2003.6 太原师范学院化学系，本科

2003.9-2006.6 山西大学分子科学研究所，无机化学 硕士

2008.9-2014.6 山西大学化学化工学院，分析化学 博士

工作经历：

2006.9-2008.6 中北大学理学院

2012.8-2013.2 香港浸会大学，理学院化学系，交换生

2014.7-至今 山西大学，环境科学研究所，副教授

2020.11-2021.5 中科院山西煤化所，煤转化国家重点实验室，访问学者

主要科研成果：

主持项目：

山西省科技厅基础研究计划项目（批准号：202303021221066，项目名称：近红外乙酰胆碱酯酶特异性荧光探针的合成及其在脑神经成像中的应用），10万元，在研，主持。

国家自然科学青年基金项目（项目编号：81901814，项目名称：靶向线粒体的近红外比率型过氧化氢荧光探针对线粒体自噬进程的可视化监测），20万元，已结题，主持。

研究开发类项目应用研究（合同编号：02050116100046，项目名称：pH荧光探针的合成及应用），15万元，已结题，主持。

山西省科技厅基础研究计划项目（批准号：201601D21036，项目名称：具有细胞器靶向定位功能的比率型pH荧光探针的设计合成及细胞成像），3万元，已结题，主持。

山西省教育厅高校科技创新项目（批准号：2016108，项目名称：具有线粒体靶向和近红外发光的比率型pH荧光探针的合成及细胞成像研究），3万元，已结题，主持。

发表论文：

Xue Yu, Yunong Huang, Yunqi Tao, Li Fan*, Yuewei Zhang*. Mitochondria-targetable small molecule fluorescent probes for the detection of cancer-associated biomarkers: A review. Analytica Chimica Acta, 2024, 1289, 342060.

Ling Ma*, Qi Zan, Baozhu Zhang, Wenjia Zhang, Chunmiao Jia*, Li Fan*. A multi-functional fuorescent probe for visualization of H2S and viscosity/polarity and its application in cancer imaging. Analytical and Bioanalytical Chemistry, 2024, 416, 1375−1387.

Li Fan*, Qianqian Yang, Qi Zan, Kunyi Zhao, Wenjing Lu, Xu Wang, Yu Wang, Shaomin Shuang, Chuan Dong*. Multifunctional Fluorescent Probe for Simultaneous Detection of ONOO−, Viscosity, and Polarity and Its Application in Ferroptosis and Cancer Models. Analytical Chemistry, 2023, 95, 5780−5787.

Qi Zan, Li Fan*, Ling Ma, Qianqian Yang, Kunyi Zhao, Yue Huang, Chuan Dong, Shaomin Shuang*. Dual-channel fluorescent probe for simultaneously detecting H2S and viscosity/polarity and its application in non-alcoholic fatty liver, tumor tissue, and food spoilage. Sensors & Actuators: B. Chemical, 2023, 397, 134596.

Xue Yu, Yunong Huang, Ning Zhang, Qi Zan, Xiaodong Wang, Zhuping Jin, Li Fan*, Chuan Dong, Yuewei Zhang*. A lipid droplet-targeting fluorescent probe for specific H2S imaging in biosamples and development of smartphone platform. Analytica Chimica Acta, 2023, 1277, 341679.

Wenjing Lu*, Yanjiao Guo, Yongfang Yue, Jinghua Zhang, Li Fan, Feng Li, Yi Zhao, Chuan Dong, Shaomin Shuang*. Smartphone-assisted colorimetric sensing platform based on molybdenum-doped carbon dots nanozyme for visual monitoring of ampicillin. Chemical Engineering Journal, 2023, 468, 143615.

Shuohang Wang, Yuewei Zhang*, Xiaodong Wang, Qi Zan, Xue Yu, Li Fan*. An esterase-sensitive AIEgen probe targeting mitochondria and lipid droplets for assessing cell viability. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 287, 122122.

Li Fan*, Qi Zan, Xiaodong Wang, Xue Yu, Shuohang Wang, Yuewei Zhang*, Qianqian Yang, Wenjing Lu, Shaomin Shuang, Chuan Dong*. A mitochondria-targeted and viscosity-sensitive near-infrared fluorescent probe for visualization of fatty liver, inflammation and photodynamic cancer therapy. Chemical Engineering Journal, 2022, 449, 137762.

Yuewei Zhang, Shuohang Wang, Ning Zhang, Xiaodong Wang, Qi Zan, Li Fan*, Xue Yu*, Shaomin Shuang, Chuan Dong*. Three Birds with one stone: A single AIEgen for dual-organelle imaging, cell viability evaluation and photodynamic cancer cell ablation. Materials Chemistry Frontiers, 2022, 6, 333−340.

Yuewei Zhang, Ning Zhang, Shuohang Wang, Qi Zan, Xiaodong Wang, Qianqian Yang, Xue Yu*, Chuan Dong, Li Fan*. A lipid droplet-targetable and biothiol-sensitive fluorescent probe for the diagnosis of cancer cells/tissues. Analyst, 2022, 147, 1695−1701.

Wenjing Lu*, Yanjiao Guo, Jinghua Zhang, Yongfang Yue, Li Fan, Feng Li, Chuan Dong, Shaomin Shuang. A high catalytic activity nanozyme based on cobalt-doped carbon dots for biosensor and anticancer cell effect. ACS Applied Materials & Interfaces, 2022, 14, 57206−57214.

Ling Ma*, Qianqian Yang, Qi Zan, Haiyan Tian, Xiaohua Zhang, Chuan Dong, Li Fan*. A benzothiazole-based fluorescence probe for imaging of peroxynitrite during ferroptosis and diagnosis of tumor tissues. Analytical and Bioanalytical Chemistry, 2022, 414, 7753−7762.

Chunmiao Jia, Xiaodong Wang, Qi Zan, Qianqian Yang, Yubin Wang, Xue Yu, Yuewei Zhang*, Chuan Dong, Li Fan*. A water-soluble 1,8-naphthalimide-based fluorescent pH probe for distinguishing tumorous tissues and inflammation in mice. Luminescence, 2022, 37, 1395−1403.

Li Fan*, Xiaodong Wang, Qi Zan, Lifang Fan, Feng Li, Yongming Yang, Caihong Zhang, Shaomin Shuang, Chuan Dong*. Lipid Droplet-Specific Fluorescent Probe for In Vivo Visualization of Polarity in Fatty Liver, Inflammation, and Cancer Models. Analytical Chemistry, 2021, 93, 8019−8026（ESI 1%高被引论文）.

Xiaodong Wang, Li Fan*, Qi Zan, Shuohang Wang, Yuewei Zhang*, Shaomin Shuang, Chuan Dong*. Real-Time Monitoring Mitochondrial Viscosity during Mitophagy Using a Mitochondria-Immobilized Near-Infrared Aggregation-Induced Emission Probe. Analytical Chemistry, 2021, 93, 3241−3249.

Li Fan*, Qi Zan, Xiaodong Wang, Shuohang Wang, Yuewei Zhang*, Wenjuan Dong, Shaomin Shuang, Chuan Dong*. A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and H2O2 in Inflammation and Tumor Models. Chinese Journal of Chemistry, 2021, 39, 1303−1309.

Li Fan*, Jinyin Ge, Qi Zan, Xiaodong Wang, Shuohang Wang, Yuewei Zhang*, Wenjuan Dong, Shaomin Shuang, Chuan Dong*. Real-time tracking the mitochondrial membrane potential by a mitochondria-lysosomes migration fluorescent probe with NIR-emissive AIE characteristics. Sensors and Actuators B: Chemical, 2021, 327, 128929.

Yuewei Zhang, Shouhang Wang, Ning Zhang, Qi Zan, Xiaodong Wang, Xue Yu*, Li Fan*, Chuan Dong. Monitoring of the decreased mitochondrial viscosity during heat stroke with a mitochondrial AIE probe. Analytical and Bioanalytical Chemistry, 2021, 413: 3823−3831.

Wenjuan Dong*, Jiangyan Yu, Xiaojuan Gong*, Wenting Liang, Li Fan, Chuan Dong. A turn-off-on near-infrared photoluminescence sensor for sequential detection of Fe3+ and ascorbic acid based on glutathione-capped gold nanoclusters. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 247, 119085.

Xiaodong Wang, Li Fan*, Xiaoran Zhang, Qi Zan, Wenjuan Dong, Shaomin Shuang, Chuan Dong*, A red-emission fluorescent probe for visual monitoring of lysosomal pH changes during mitophagy and cell apoptosis. Journal of Materials Chemistry B, 2020, 8, 1466.

Bo Lin, Li Fan, Ying Zhou, Jinyin Ge, Xueli Wang, Chuan Dong, Shaomin Shuang*, Man Shing Wong*. A benzothiazolium-based fluorescent probe with ideal pKa for mitochondrial pH imaging and cancer cell differentiation. Journal of Materials Chemistry B, 2020, 8, 10586−10592.

Li Fan*, Qi Zan, Bo Lin, Xiaodong Wang, Xiaojuan Gong, Zhonghua Zhao, Shaomin Shuang, Chuan Dong*, Man Shing Wong*. Hypoxia imaging in living cells, tissues and zebrafish with a nitroreductase-specific fluorescent probe. Analyst, 2020, 145, 5657−5663.

Xiaodong Wang, Li Fan*, Yubin Wang, Caihong Zhang, Wenting Liang, Shaomin Shuang, Chuan Dong*. Visual monitoring of the lysosomal pH changes during autophagy with a red-emission fluorescent probe. Analyst, 2020, 145, 7018-7024.

Lin, Bo#; Fan, Li#; Zhou, Ying; Ge, Jinyin; Wang, Xueli; Zhang, Tongxin; Dong, Chuan; Shuang, Shaomin*; Wong, Manshing*. The ratiometric fluorescent probe with high quantum yield for quantitative imaging of intracellular pH. Talanta, 2020, 208, 120279.

杨倩倩, 昝琪, 王硕航, 于雪, 张跃伟*, 董川, 樊丽*. 一种用于过氧亚硝酸根检测的长波长发射比率荧光探针. 山西大学学报（自然科学版），2023, 46, 220−228.

李佳乐, 樊丽, 李苗, 双少敏, 张彩红*. 基于NBD胺硫解反应的硫化氢荧光探针. 山西大学学报（自然科学版），2021, 1−9.

Fan, Li#,*; Wang, Xiaodong#; Ge, Jinyin; Li, Feng*; Zhang, Caihong; Lin, Bo; Shuang, Shaomin and Dong, Chuan*. A Golgi-targeted off–on fluorescent probe for real-time monitoring of pH changes in vivo. Chemical Communication, 2019, 55: 6685-6688 (Cover paper).

 Jinyin Ge, Kai Zhang,* Li Fan, Xiaodong Wang, Caihong Zhang, Chuan Dong, Man Shing Wong*, Shaomin Shuang*. Novel long-wavelength emissive lysosome-targeting ratiometric fluorescent probes for imaging in live cells. Analyst, 2019, 144, 4288-4294.

Fan, Li#,*; Wang, Xiaodong#; Ge, Jinyin; Li, Feng*; Wang, Xiao; Wang, Juanjuan; Shuang, Shaomin and Dong, Chuan*. A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis. Chemical Communication, 2019, 55: 4703-4706.

Fan, Li#,*; Zhang, Wenjia#; Wang, Xiaodong; Dong, Wenjuan; Tong, Yaoli; Dong, Chuan; Shuang, Shaomin*. A two-photon ratiometric fluorescent probe for highly selective sensing of mitochondrial cysteine in live cells. Analyst, 2019, 144(2): 439-447 (Cover paper).

Wang, Xiaodong#; Fan, Li#,*; Ge, Jinyin; Li, Feng; Zhang, Caihong; Wang, Juanjuan; Shuang, Shaomin; Dong, Chuan*. A lysosome-targetable fluorescent probe for real-time imaging cysteine under oxidative stress in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 221: 117175-117184.

Hou, Lingjie#; Fan, Li#; Guo, Jinchang; Zhang, Xiaoying, Kong, Xiangyu; Cui Tracy, Xinyan; Dong, Chuan; Wang, Yu*; Shuang, Shaomin*. A colorimetric and ratiometric fluorescent probe for cyanide sensing in aqueous media and live cells. Journal of Materials Chemistry B, 2019, 7, 4620-4629 (Cover paper).

Fan, Li*; Nan, Ming; Ge, Jinyin; Wang, Xiaodong; Lin, Bo; Zhang, Wenjia; Shuang, Shaomin; Dong, Chuan*. Imaging of lysosomal pH changes with a novel quinoline/benzothiazole probe. New Journal of Chemistry, 2018, 42(16): 13479-13485.

Lin, Bo#; Fan, Li#; Ge, Jinyin; Zhang, Wenjia; Zhang, Caihong; Dong, Chuan and Shuang, Shaomin*. A naphthalene-based fluorescent probe with a large Stokes shift for mitochondrial pH imaging. Analyst, 2018, 143: 5054-5060.

Zhang, Wenjia#; Fan, Li#; Li, Zengbo; Ou, Ting; Zhai Huajin; Yang, Jun; Dong, Chuan and Shuang, Shaomin*. Thiazole-based ratiometric fluorescence pH probe with large Stokes shift for intracellular imaging. Sensors and Actuators B: Chemical, 2016, 233: 566-573.

Fan, Li; Gao, Shouqin; Li, Zengbo; Niu, Weifen; Zhang, Wenjia; Shuang, Shaomin; Dong, Chuan*. An indole-carbazole-based ratiometric emission pH fluorescent probe for imaging extreme acidity. Sensors and Actuators B: Chemical, 2015, 221: 1069-1076.

Fan, Li; Liu, Qiaoling; Lu, Dongtao; Shi, Heping; Yang, Yunfeng; Li, Yingfu; Dong, Chuan; Shuang, Shaomin*. A novel far-visible and near-infrared pH probe for monitoring near-neutral physiological pH changes: imaging in live cells. Journal of Materials Chemistry B, 2013, 1(34): 4281-4288.

Fan, Li; Fu, Yuejun; Liu, Qiaoling; Lu, Dongtao; Dong, Chuan; Shuang, Shaomin*. Novel far-visible and near-infrared pH probes based on styrylcyanine for imaging intracellular pH in live cells. Chemical Communication, 2012, 48(91): 11202-11204.

授权及转化专利：

1. 樊丽，葛金印，林博，南明，董川，双少敏。苯并噻唑类的溶酶 体靶向型pH荧光探针及其制备和应用。专利号：ZL 201610911985.2。已转化2万

2. 樊丽，林博，葛金印，董川，双少敏。一种萘基衍生物作为线粒体靶向型pH荧光探针的应用。ZL 201610960390.6。已转化2万

3. 樊丽，昝琪，张跃伟。一种双通道检测粘度和过氧化氢的荧光探针及制备和应用。ZL 201911223419.2

4. 樊丽，昝琪，王晓东，董川， 双少敏。一种苯并噻唑类衍生物作为硝基还原酶荧光探针及应用。ZL 201911223419.2。

5. 樊丽，王晓东，李峰，董川。监测线粒体自噬的罗丹明类pH荧光探针及制备和应用。 ZL 201911284349.1。

6. 樊丽，王宇斌，董川，双少敏。一种1,8-萘二甲酰亚胺衍生物及应用。ZL 201911223415.4。

7. 樊丽，王晓东，葛金印，董川，双少敏。一种基于罗丹明B的衍生物及其制备方法和应用。ZL 201810802359.9。

8. 樊丽，张雯佳，王晓东，葛金印，董川，双少敏。一种萘基双光子荧光探针及其制备方法和应用。ZL 201710292854.5。

9. 樊丽，王晓东，张跃伟，李峰，董川。一种线粒体-溶酶体迁移型膜电位荧光探针CSP。ZL 202010768534.4。

10. 樊丽，林博，贾晶，王晓东，双少敏，董川。一种苯并噻唑衍生物NTNO及其制备方法和应用。ZL 201811349638.0。

11. 樊丽，李增波，高首勤，牛卫芬，董川，双少敏。咔唑类比率型pH荧光探针及其制备方法和应用。ZL 201510050282.0。

12.  林博，樊丽，贾晶，黄文成，双少敏，董川。一种基于苯并噻唑的线粒体pH荧光探针及其制备方法。ZL 201811194600.0。

13.  林博，樊丽，贾晶，黄文成，双少敏，董川。一种苯并噻唑衍生物及其制备方法和应用。ZL 201811347673.9。

14. 王晓东，樊丽，葛金印，董川，双少敏。一种咔唑衍生物MCAB及其制备方法和应用。ZL 201811552686.X。

15. 王晓东，樊丽，李明璐，董川，双少敏。一种床头风扇。ZL 201921388851.2。

16. 葛金印，樊丽，梁文婷，张凯，张雯佳，双少敏，黄文成，董川。一种双光子溶酶体pH荧光探针及其制备方法和应用。ZL 201710149868.1。

17. 牛卫芬，樊丽，武庭瑄，钞建斌，双少敏，董川。一种极度酸性pH荧光探针及其制备方法和应用。ZL 201410262408.6。

18. 南明，牛卫芬，樊丽，双少敏，董川。一种丙烯醛衍生物的新途径。ZL 201510027794.5。

19. 王晓东，杨亚娟，董川，樊丽，双少敏。一种便携式通风蚊帐。ZL 202021670494.1。

20. 董文娟，尉江燕，弓晓娟，梁文婷，樊丽，董川。一种近红荧光增敏法测定葡萄糖。ZL 201811417097.0。

三、获奖情况

1. 2023年获得山西省科学技术奖二等奖（排名第二，获奖人名单为：双少敏，樊丽，董川，王煜，石利红），项目名称：多功能荧光成像探针研究与应用。

2. 2017年获得山西省科学技术奖二等奖（排名第三，获奖人名单为：双少敏，张彦，樊丽，董川，弓晓娟，石利红），项目名称：发光探针的构筑及性能研究。

2. 荣获2013年博士研究生国家奖学金。

3. 荣获2014年山西大学博士研究生优秀毕业论文。

4. 2008年获得山西省高等学校科技进步二等奖（排名第五，获奖人名单为：杨频，韩大熊，焦勇，张朝峰，樊丽，贾卫平），项目名称：老年痴呆症的分子机理研究。