Contact Information
Professor & doctoral advisor in Environmental Toxicology
& Environmental pollution and Health
Shanxi University
Dean of the College of Environment & Resources (in-service)
Member of Communist Party of China
Research direction and courses
Research direction: Environmental Toxicology of Environmental Sciences
Courses:
1. Environmental Biology and Experiment
2. Environmental Toxicology
3. Cytobiology
University Education and Teaching experiences
Post-Doc. Environmental Sciences, 2004-2006
Louisiana University Health Science Center，LSUHSC
Ph.D. Environmental Sciences, 1999-2002
Shanxi University, Taiyuan, Shanxi
Teacher,1998
College of Environment & Resources of Shanxi University
M.S. Environmental Sciences, 1995
Shanxi University, Taiyuan, Shanxi
B.S. Environmental Sciences, 1991
Shanxi University, Taiyuan, Shanxi
Publications
As the first author or corresponding author, the author has published more than 50 papers in SCI core journals, and more than 30 papers in SCI core journals in the past five years (6 papers in TOP 1 Section of SCI), including one paper published in the Journal Environmental Health Perspectives, 3 papers in Environmental Science & Technology, 2 papers in Particle and Fibre Toxicology, 1 paper in Scientific Reports published by Nature, 2 papers in Toxicological Science which is internationally renowned journal in the field of Toxicology, 1 paper in Chemical Research in Toxicology the exclusive journal for research of Toxicity of Chemical Compounds in the Chemical Society in America.. The author’s publications have been cited more than 700 times by the journals including Chemical Reviews, Physiological Reviews, Nature Reviews Neuroscience and so on. (In the past five years, the author’s all publications have been cited more than 430 times, and the most popular one has been cited more than 60 times.) And the author has attended academic conference several times at home and abroad. The representative papers are as follow:
1 Han Ming，Guo Zhen，Li Guangke，Sang Nan(*)，Nitrogen dioxide inhalation induces gene-toxicity in rats，Chemosphere，2013，90（11）：2737-2742。
2 Zhu Na，Li Hongyan，Li Guangke，Sang Nan(*)，Coking wastewaterincreases micronucleus frequency in mouse in vivo via oxidative stress，Journal of Environmental Sciences，2013，25（10）：2123-2129。
3 Yun Yang (#)，Yao Gaoyi (#)，Yue Huifeng，Guo Lin，Guohua Qin，LiGuangke，Sang Nan(*)，SO2 inhalation causes synaptic injury in rat hippocampusvia its derivatives invivo，Chemosphere，2013，93（10）：2426-2432。
4 Yao Gaoyi，Yue Huifeng，Yun Yang，Sang Nan(*)，Chronic SO2 inhalationabove environmental standard impairs neuronal behavior and represses glutamatereceptor gene expression and memory- related kinase activation via neuro inflammation in rats，Environmental Research，2015，137（0）：85-93。
5 Ji Xiaotong，Han Ming，Yun Yang，Li Guangke，Sang Nan(*)，Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulatingTh1/Th2 differentiation and activating JAK-STAT pathway，Chemosphere，2015，120（0）：722-728。
6 Ku Tingting，Yan Wei，Jia Wuyao，Yun Yang，Zhu Na，Li Guangke，SangNan(*)，Characterization of synergistic embryo toxicity of nickel and buprofezin in zebrafish，Environmental Science &Technology，2015，49（7）：4600-4608。
7 Yun Yang，Gao Rui，Yue Huifeng，Li Guangke，Zhu Na，Sang Nan(*)，Synergistic effects of particulate matter (PM10) and SO2 on human non-small celllung cancer A549 via ROS-mediated NF-κB activation，Journal of Environmental Sciences-China，2015，31（0）：146-153。
8 Li Ben，Chen Minjun，Guo Lin，Yun Yang，Li Guangke，Sang Nan(*)，Endogenous 2-arachidonoylglycerol alleviates cyclooxygenases-2 elevation-mediated neuronal injury from SO2 inhalation via PPARγ pathway，Toxicological Science，2015，147（2）：535-548。
9 Yue Huifeng(#)，Yun Yang(#)，Gao Rui，Li Guangke，Sang Nan(*)，Winter polycyclic aromatic hydrocarbon-bound particulate matter from peri-urban North China promotes lung cancer cell metastasis，Environmental Science &Technology，2015，49（24）：14484-14493。
10 Yan Wei(#) ，Yun Yang(#) ，Ku Tingting，Li Guangke， Sang Nan(*)，NO2inhalation promotes Alzheimer’s disease-like progression:cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerollipase inhibition-targeted medication，Scientific Reports, 2016，6：22429。
11 Liang Dong (#)，Zhu Na(#) ，Zhu Hailin，Hu Zhiyong，Cao Duanlin，Sang Nan(*)，Improvement of the polyoxometalate's performance in the asymmetricoxidation of styrene via combined with chiral ionic liquid，Catalysis Communications，2016，79（0）：49-52。
12 Yao Gaoyi, Yun Yang, Sang Nan(*). Differential effects between one week and four weeks exposure to same mass of SO2 on synaptic plasticity in rat hippocampus. Environmental Toxicology, 2016, 31:820-9.
13 Zhang Yingying, Ji Xiaotong, Ku Tingting, Li Guangke, Sang Nan(*).Heavy metals bound to fine particulate matter from northern China induce season-dependent health risks: A study based on myocardial toxicity. Environmental Pollution, 2016, 216:380-90.
14 Ji Xiaotong, Zhang Yingying, Ku Tingting, Yun Yang, Li Guangke, Sang Nan(*). MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway. Toxicological Research, 2016, 320: 1548-1560.
15 Sun Haifeng, Guo Shuai, Zhu Na, Sang Nan(*), Chen Zhang. In situ determination of multiple polycyclic aromatic hydrocarbons uptake by crop leaf surfaces using multi-way models.Environmental Pollution, 2016, 218:523-529.
16 Ku Tingting, Ji Xiaotong, Zhang Yingying, Li Guangke, Sang Nan(*).PM2.5, SO2 and NO2 co-exposure impairs neuro behavior and induces mitochondrial injuries in the mouse brain. Chemosphere, 2016, 163:27-34.
17 Zhang Yingying，Ji Xiaotong，Ku Tingting，Sang Nan(*)，Inflammatory response and endothelial dysfunction in the hearts of mice co-exposed to SO2,NO2 and PM2.5，Environmental Toxicology, 2016, 31(12):1996-2005。
18 Ji Xiaotong(#), Ku Tingting(#), Zhu N, Ning X, Wei W, Li G, Sang N(*).Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism. Journal of Hazardous Materials, 2016, 320:176-186.
19 Li Ben, Chen Minjun, Guo Lin, Yun Yang, Li Guangke, Sang Nan(*). Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain.J Environ Sci (China). 2017, 51:265-274
20 Ku Tingting(#), Chen Minjun(#), Li Ben, Yun Yang, Li Guangke, Sang Nan(*),Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation , Toxicological Research, 2017,6, 7-16.
21 Yun Yang(#), Gao Rui(#), Yue Huifeng, Liu Xiaofang, Li Guangke, Sang Nan(*). Polycyclic aromatic hydrocarbon (PAH)-containing soils from coal gangue stacking areas contribute to epithelial to mesenchymal transition (EMT) modulation on cancer cell metastasis. Science of the Total Environment, 2017, 580:632-640.
22 Chen Minjun, Li Ben, Sang Nan(*). Particulate matter (PM2.5) exposure season-dependently induces neuronal apoptosis and synaptic injuries. J Environ Sci (China). 2017, 54:336-345.
23 Ku Tinging, Li Ben, Gao Rui, Zhang Yingying, Yan Wei, Ji Xiaotong, Li Guangke, Sang Nan(*).NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration. Part Fibre Toxicol. 2017, 14(1):34.
24 Ku Tingting, Zhang Yingying, Ji Xiaotong, Li Guangke, Sang Nan(*).PM2.5-bound metal metabolic distribution and coupled lipid abnormality at different developmental windows.Environmental Pollution, 2017, 228:354-362.
25 Yue Huifeng，Yan Wei，Ji Xiaotong，Gao Rui，Ma Juan，Rao Ziyu，LiGuangke，Sang Nan(*), Maternal Exposure of Balb/cMice to Indoor NO2 and AllergicAsthma Syndrome in Offspring at Adulthood with evaluation of DNA Methylation Associated Th2 Polarization，Environmental Health Perspectives, 2017, 125(9):097011.
26 Yun Yang(#), Gao Rui(#), Yue Huifeng, Guo Lin, Li Guangke, Sang Nan(*). Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically 2 Regulatingthe Epithelial-to-Mesenchymal Transition (EMT)，Environmental Science &Technology, 2017, 51(19):11401-11411.
27 Sun Haifeng, Feng Ruijie, Nan Yanli, Chen Zhang, Sang Nan(*).In-situ examination of graphene and graphene oxide impact on the depuration of phenanthrene and fluoranthene adsorbed onto spinach (Spinacia oleracea L.) leaf surfaces. Environmental Pollution, 2017，pii: S0269-7491(17)32893-2.
28 Li Ben, Guo Lin, Ku Tingting, Chen Minjun, Li Guangke, Sang Nan(*).PM2.5 exposure stimulates COX-2-mediated excitatory synaptic transmission via ROS-NF-κB pathway.Chemosphere, 2018, 190:124-134.
29 Ji Xiaotong(#), Zhang Yingying(#), Li Guangke, Sang Nan(*).Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure. Current Pharmaceutical Design. 2018. doi: 10.2174/1381612824666180110150550.
30 Ning Xia, Ku Tingting, Gao Rui, Ji Xiaotong, Li Guangke, Sang Nan(*). In vitro PPARγ agonistic potential of chitin synthesis inhibitors and their energy metabolism-related hepatotoxicity. Science of the Total Environment 2018, 615: 1126–1132.
31 Zhang Yingying, Yan Wei, Ji Xiaotong, Yue Huifeng, Li Guangke, Sang Nan(*). Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1α transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5. Arch Toxicol. 2018, 92(4):1563-1579.
32 Yue Huifeng, Yan Wei, Ji Xiaotong, Zhang Yingying, Li Guangke (*), Sang Nan(*). Maternal exposure to NO2 enhances airway sensitivity to allergens in BALB/c mice through the JAK-STAT6 pathway. Chemosphere. 2018, 200:455-463.
33 Ning Xia, Wang Yue, Yan Wei, Li Guangke, Sang Nan(*). Chitin synthesis inhibitors promote liver cancer cell metastasis via interfering with hypoxia-inducible factor 1α. Chemosphere. 2018, 206:231-237.
34 Qin Guohua, Xia Jin, Zhang Yingying, Guo Lianghong, Chen Rui, Sang Nan(*). Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice. Part Fibre Toxicol. 2018, 15(1):27.
35 Ning Xia, Li Ben, Ku Tingting, Guo Lin, Li Guangke, Sang Nan(*). Comprehensive hippocampal metabolite responses to PM2.5 in young mice. Ecotoxicol Environ Saf. 2018, 165:36-43.